February 26, 2019

Our areas

INDICATE technology

The INDICATE device is a single-use disposable device inspired by nature and influenced by next generation mass-market IVDs such as the ClearBlue™ ovulation test. It requires no prior manipulation of the blood, no expensive equipment, readers, or specialised personnel, has no external power requirements, it is handheld, small and rapid generating a simple visible yes/no answer. The device is a hybrid microfluidics-lateral flow device, the microfluidics section is powered by Degas flow via specially designed micropumps as a result of the device being packaged under negative pressure, whilst the lateral flow test signal region is powered by capillary force. Button-batteries power the on-device electronics.

The specificity of the INDICATE device comes from specific binding of the mutated DNA sequence to specially designed probe sequences. The trigger mechanism is caused by the agglomeration of nanoparticles attached to these probes. The sensitivity of the device comes from the selective release of tens of millions of signal molecules only in the presence of the trigger; this amplification process is analogous to signalling cascades in living cells.

 

 

Opportunity

The INDICATE device concept is a rapid point-of-care (POC) companion diagnostic device to detect cancer-specific mutations from blood (liquid biopsies) in a quick and simple manner.

Global liquid biopsy market will be $4.5 billion by 2020

Cancer liquid biopsy market has a five-year CAGR of 36.2%

Millions funded into companies already

2.78 million potential users worldwide for lung cancer alone

Unique selling points of INDICATE device:

  • Single-use disposable
  • No laboratory equipment/specialised personnel required
  • Rapid (minutes) yes/no answer
  • Economical
  • Platform technology rapidly adaptable to new indications including:
    • personalised medicine (cancer), infectious disease, environmental monitoring, veterinary use, extreme environments etc.

 

Bioinformatics Solutions

We offer investigators biostatistical, bioinformatic, and sequencing consultation services to guide researchers towards the effective design, execution, and analysis of their studies and research questions. We provide advanced bioinformatics services for next generation sequence (NGS) analysis, array analysis, as well as other types of OMICs data analysis (including transcriptomics, proteomics and metabolomics) of human, non-human and extinct species using open source tools, for research purposes.

Our highly qualified bioinformaticians will be with you every step of the way to offer a bespoke solution to your bioinformatic solutions. Contact us for further details